Which clinical manifestations is the patient likely to show when he or she has reached stage 2 of the Unified Parkinson's Disease Rating Scale (UPDRS)? Akinesia, rigidity, and severe disability Early postural changes, social withdrawal, and depression Substantial gait disturbances and moderate generalized disability slight tremors or minor changes in speech, facial expression, posture, or movement

To determine the clinical manifestations associated with stage 2 of the Unified Parkinson's Disease Rating Scale (UPDRS), we can analyze the options provided: 1. **Akinesia, rigidity, and severe disability**: This description is more indicative of later stages of Parkinson's disease, where significant motor symptoms and disability are present. 2. **Early postural changes, social withdrawal, and depression**: While these symptoms can occur in Parkinson's disease, they are not specific to stage 2 and may appear in earlier or later stages. 3. **Substantial gait disturbances and moderate generalized disability**: This suggests a more advanced stage of the disease, likely beyond stage 2. 4. **Slight tremors or minor changes in speech, facial expression, posture, or movement**: This aligns with stage 2, where symptoms are typically bilateral but not yet severe enough to cause significant disability. Based on the characteristics of stage 2 in the UPDRS, the most appropriate answer is: **Slight tremors or minor changes in speech, facial expression, posture, or movement.**