Question
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Which adverse effect can diphenhydramine hydrochloride have on the patient?
gastrointestinal system?
Nausea
Diarthea
Anorexia
Constipation

Ask by Weber Cox. in the United States
Jan 21,2025

Upstudy AI Solution

Tutor-Verified Answer

Answer

Constipation is a gastrointestinal adverse effect of diphenhydramine hydrochloride.

Solution

Diphenhydramine hydrochloride, a first-generation antihistamine, exhibits several anticholinergic (antimuscarinic) effects. These effects can impact various body systems, including the gastrointestinal (GI) system.
Common GI Adverse Effects of Diphenhydramine:
  1. Constipation: This is one of the most commonly reported GI side effects due to the antimuscarinic action, which decreases intestinal motility.
  2. Dry Mouth: While not directly a GI effect, reduced saliva production can contribute to discomfort in the mouth and throat.
  3. Nausea: Some patients may experience mild nausea, although it’s less common compared to constipation.
Less Common or Unrelated Effects:
  • Diarrhea: Generally, diphenhydramine is more likely to cause constipation rather than diarrhea due to its anticholinergic properties.
  • Anorexia: While a decreased appetite can occur, it’s not as consistently associated with diphenhydramine as constipation is.
Conclusion:
Among the listed options—nausea, diarrhea, anorexia, and constipation—constipation is the most directly associated gastrointestinal adverse effect of diphenhydramine hydrochloride.
Answer:
Constipation is a gastrointestinal adverse effect that diphenhydramine hydrochloride can cause.

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Extra Insights

Diphenhydramine hydrochloride, an antihistamine often used for allergies, can indeed cause a few less-than-desirable effects on the gastrointestinal system. One noteworthy adverse effect is constipation, as diphenhydramine can slow down the digestive system, leading to less frequent bowel movements. If you find yourself feeling backed up after taking this medication, you’re not alone!
Additionally, while nausea can be a side effect as well, it’s interesting to note that the drug may also impact appetite, leading to anorexia—basically a fancy term for loss of interest in eating. Remember, if you’re experiencing any unusual symptoms, it’s a good idea to check in with a healthcare professional!

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