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Testing for a disease can be made more efficient by combining samples. If the samples from four people are combined and the mixture tests positive sample will always test positive, no matter how many negative samples it is mixed with. Assuming the probability of a single sample samples combined into one mixture. Is the probability low enough so that further testing of the individual samples is rarely necessary? The probability of a positive test result is \( \square \). (Round to three decimal places as needed.)

Ask by Fleming Weber. in the United States
Feb 03,2025

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Answer

The probability that a pooled sample of four individuals tests positive is \( 1 - (1 - p)^4 \), where \( p \) is the probability of a single sample being positive.

Solution

To determine the probability that a pooled sample of four individuals tests positive, we need to consider the probability that **at least one** of the four individual samples is positive. Let's denote: - \( p \) as the probability that a single individual sample is positive. - \( 1 - p \) as the probability that a single individual sample is negative. When you pool four samples together: - The only way the pooled sample tests negative is if **all four** individual samples are negative. - The probability that all four samples are negative is \( (1 - p)^4 \). Therefore, the probability that the pooled sample **tests positive** is the complement of all samples being negative: \[ \text{Probability of positive pooled test} = 1 - (1 - p)^4 \] **Rounded to three decimal places:** \[ \boxed{1 - (1 - p)^4} \] **Example Calculation:** If, for instance, the probability \( p \) of a single sample being positive is 0.05 (5%), then: \[ 1 - (1 - 0.05)^4 = 1 - (0.95)^4 \approx 1 - 0.8145 = 0.1855 \approx 0.186 \] So, the probability of the pooled test being positive would be **0.186** when \( p = 0.05 \). **Conclusion:** Without a specific value for \( p \), the general formula for the probability of a positive pooled test is: \[ \boxed{1 - (1 - p)^4} \] You can plug in the specific probability \( p \) to find the numerical probability rounded to three decimal places.

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To determine if further testing is rarely necessary, let’s first clarify the probability of a positive test result when samples are combined. If the probability of a single sample testing positive is \( p \), you can find the probability of the combined sample testing negative, which is \( (1 - p)^4 \) for four samples. Thus, the probability of the combined sample testing positive would be: \[ P(\text{positive}) = 1 - (1 - p)^4 \] If \( p \) is low enough (for example, let’s say \( p = 0.1\)), then: \[ P(\text{positive}) = 1 - (0.9)^4 \approx 1 - 0.6561 = 0.3439 \] Rounded to three decimal places, this gives \( P(\text{positive}) = 0.344 \). If further testing of individuals is conducted rarely, you'd generally want this probability to be less than 0.1, suggesting you're combining samples effectively. With lower \( p \), the benefit is even more pronounced!

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