How do centrally acting anticholinergics help control symptoms in Parkinson's disease By blocking cholinergic receptors By activating dopaminergic receptors By preventing destruction of dopamine-producing cells in the central nervous system (CNS) By increasing the synthesis of dopamine

Centrally acting anticholinergics work primarily by blocking cholinergic receptors in the brain, which helps to restore the balance between acetylcholine and dopamine. This is particularly beneficial in Parkinson's disease, where the loss of dopaminergic neurons leads to an excess of acetylcholine, contributing to symptoms like tremors and rigidity. By curbing this cholinergic activity, these medications can help ease motor symptoms, allowing for improved control of movement and better quality of life. Interestingly, despite not addressing the primary dopaminergic deficits in Parkinson's, centrally acting anticholinergics have been used for decades. They are especially effective in treating tremors and rigidity, reminding us that finding the right balance in brain chemistry can often involve unexpected approaches. However, they may not be suitable for everyone, especially older patients, due to potential side effects like confusion or dry mouth.