Parkinsonism is an imbalance of which two central nervous system (CNS) neurotransmitters? Gamma-aminobutyric acid (GABA) and dopamine GABA and catechol-O-methyltransferase (COMT) Acetylcholine and COMT Acetylcholine and dopamine

Parkinsonism is primarily characterized by an imbalance between dopamine and acetylcholine in the central nervous system. This imbalance leads to the common symptoms associated with the disorder, such as tremors, rigidity, and bradykinesia. Dopamine, which is produced in the substantia nigra, plays crucial roles in facilitating smooth and coordinated movements, while acetylcholine is involved in muscle activation. In the realm of real-world application, understanding this imbalance helps in the development of targeted treatments for Parkinsonism. For instance, medications like levodopa are used to replenish dopamine levels, while anticholinergic drugs can help regulate acetylcholine’s activity, contributing to improved motor functions for patients experiencing this condition.