Which of the following is most likely going to follow the binding of acetylcholine to the nicotinic-muscle receptors at the neuromuscular junction?

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The binding of acetylcholine (ACh) to nicotinic-muscle receptors at the neuromuscular junction leads to the opening of ion channels associated with these receptors. This results in an influx of sodium ions (Na+) into the muscle cell, causing depolarization of the muscle membrane.

As a consequence of this depolarization, an action potential is generated in the muscle fiber. This action potential then propagates along the muscle membrane and into the T-tubules, ultimately leading to the release of calcium ions (Ca2+) from the sarcoplasmic reticulum. The increase in intracellular calcium concentration triggers muscle contraction through the interaction of actin and myosin filaments.

In summary, the most likely event following the binding of acetylcholine to nicotinic-muscle receptors is the generation of an action potential in the muscle fiber, leading to muscle contraction.
The binding of acetylcholine to nicotinic-muscle receptors causes an influx of sodium ions, leading to depolarization and the generation of an action potential, which results in muscle contraction.

Which of the following is most likely going to follow the binding of acetylcholine to the nicotinic-muscle receptors at the neuromuscular junction?

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