What is the main action of apomorphine in a patient with Parkinson's disease? It restores motor function and does not have any opioid activity. It reduces hyperstimulation caused by excessive acetylcholine. It allows a greater portion of administered levodopa to reach the basal ganglia. It slows the destruction of dopamine and helps release dopamine from its storage sites.
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Apomorphine is primarily a dopamine agonist, meaning it activates dopamine receptors, which is especially beneficial for patients with Parkinson's disease who have low levels of dopamine. This action significantly helps improve motor function and manage symptoms like bradykinesia and rigidity, highlighting its role as a fast-acting treatment during "off" periods when other medications may not be effective. Historically, dopamine replacement therapies like levodopa transformed Parkinson's treatment, but apomorphine emerged as a rescue therapy in the 2000s for acute management. Its rapid onset and effectiveness make it a go-to option for alleviating distressing symptoms, showcasing the ongoing innovation in managing chronic neurological conditions like Parkinson's disease.