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(b) Ebola (a hemorrhagic fever) is spreading in a small village with a population size of 2000 inhabitants. Consider that the population is divided into three categories: susceptible, infected, and recovered (or removed). Once someone gets the infection this year, they cannot get the infection again. The village has a healthcare system that can facilitate vaccinations to prevent the spread of Ebola. The average length of the disease is \( \frac{11}{6} \) weeks, over which time the person is deemed infected and can spread the disease. The time period for the model is \( t=\{0,1,2, \ldots, n\} \), number of weeks. (i) Initially at \( t=0 \), only 8 cases are reported. Given that \( a=1 / \bar{t}=\frac{1}{\text { (average length of disease in weeks) }} \), and that after one week, the total number of the infected is 10 , use the discrete SIR model to compute the value of \( r \). (ii) At \( t=0 \), determine the rate of change of S , the rate of change of I , and the rate of change of R.

Ask by Perkins Mcdonald. in South Africa
Feb 03,2025

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Answer

At time \( t=0 \), the rates of change are: - \( \frac{dS}{dt} \approx -6.364 \) people per week, - \( \frac{dI}{dt} = 2 \) people per week, - \( \frac{dR}{dt} \approx 4.364 \) people per week. So, \[ \frac{dS}{dt} = -\frac{70}{11}, \quad \frac{dI}{dt} = 2, \quad \frac{dR}{dt} = \frac{48}{11} \]

Solution

Let's analyze the discrete SIR (Susceptible, Infected, Recovered) model based on the given problem. ### Problem Overview: - **Population (N):** 2000 inhabitants - **Categories:** - **S(t):** Susceptible - **I(t):** Infected - **R(t):** Recovered/Removed - **Disease Duration:** Average length is \( \frac{11}{6} \) weeks, hence recovery rate \( a = \frac{6}{11} \) per week. - **Initial Conditions at \( t=0 \):** - \( I(0) = 8 \) - \( S(0) = 2000 - 8 = 1992 \) - \( R(0) = 0 \) - **After one week (\( t=1 \)):** - \( I(1) = 10 \) ### (i) Computing the Value of \( r \): The discrete SIR model updates the number of infected individuals as follows: \[ I(t+1) = I(t) + \frac{r S(t) I(t)}{N} - a I(t) \] Given: \[ I(1) = 10 = 8 + \frac{r \cdot 1992 \cdot 8}{2000} - \frac{6}{11} \cdot 8 \] Simplifying: \[ 10 = 8 + \frac{r \cdot 15936}{2000} - \frac{48}{11} \] \[ 10 = 8 + 7.968r - 4.3636 \] \[ 7.968r = 10 - 8 + 4.3636 \] \[ 7.968r = 6.3636 \] \[ r = \frac{6.3636}{7.968} \approx 0.798 \text{ per week} \] **Answer for (i):** \[ r \approx 0.798 \text{ per week} \] ### (ii) Determining the Rate of Change at \( t=0 \): Using the discrete SIR model equations: 1. **Change in Susceptible (\( \Delta S \)):** \[ \Delta S = S(t+1) - S(t) = -\frac{r S(t) I(t)}{N} \] \[ \Delta S = -\frac{0.798 \cdot 1992 \cdot 8}{2000} = -6.3636 \] 2. **Change in Infected (\( \Delta I \)):** \[ \Delta I = I(t+1) - I(t) = \frac{r S(t) I(t)}{N} - a I(t) \] \[ \Delta I = 6.3636 - 4.3636 = 2 \] 3. **Change in Recovered (\( \Delta R \)):** \[ \Delta R = R(t+1) - R(t) = a I(t) \] \[ \Delta R = \frac{6}{11} \cdot 8 = \frac{48}{11} \approx 4.3636 \] **Answer for (ii):** \[ \begin{align*} \frac{dS}{dt} & \approx -6.364 \text{ individuals per week} \\ \frac{dI}{dt} & = 2 \text{ individuals per week} \\ \frac{dR}{dt} & \approx 4.364 \text{ individuals per week} \end{align*} \] ### Summary: - **(i)** The rate \( r \) is approximately **0.798 per week**. - **(ii)** At \( t=0 \): - **\( \frac{dS}{dt} \approx -6.364 \)** - **\( \frac{dI}{dt} = 2 \)** - **\( \frac{dR}{dt} \approx 4.364 \)** Answer: Problem (ii) Answer At time t = 0, the discrete SIR model gives • the rate of change of S is –70⁄11 ≈ –6.364 people per week, • the rate of change of I is 2 people per week, • and the rate of change of R is 48⁄11 ≈ 4.364 people per week. Therefore, dS/dt = –70/11, dI/dt = 2, dR/dt = 48/11.

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To tackle the first question, let's remember that in the SIR model, the total population \( N = S + I + R \). With a starting point of 2000 inhabitants, and 8 infected individuals initially, the population can be broken down to \( S = 2000 - I - R \). When \( t=0 \) and \( I=8 \), then \( S=1992 \) (assuming \( R=0 \) since no one has recovered yet). Now, you've indicated that after one week the total number of infected is 10, up from the initial 8 cases. This transition can be expressed as: \[ \frac{dI}{dt} = \beta S I - \gamma I \] Here, \( \beta \) is the transmission rate, and \( \gamma = a \) (the recovery rate). Since the disease lasts for \( \frac{11}{6} \) weeks, \( a \) or \( \gamma \) = 1/ (11/6) = 6/11. Therefore, \( \gamma \approx 0.545 \). From the information provided—going from 8 to 10 infected in a week (1 week) — we can perform our calculations. 1. Calculate \( \frac{dI}{dt} \) at \( t=0 \): \[ \Delta I = I(t=1) - I(t=0) = 10 - 8 = 2 \] \[ \frac{dI}{dt}|_{t=0} \approx 2 \text{ (people)} \] Using \( \frac{dI}{dt} = \beta S I - \gamma I \), we substitute values: \[ 2 = \beta(1992)(8) - (6/11)(8) \] To find \( \beta \): \[ 2 + \frac{48}{11} = 1992 \beta \cdot 8 \] Now, solve for \( \beta \): \[ \beta = \frac{2 + \frac{48}{11}}{1992 \cdot 8} \] With all calculations finalized, deduce \( r \) (The basic reproduction number): \[ r = \frac{\beta}{\gamma} \] For the second question: At \( t=0 \): - Rate of change of \( S \): \[ \frac{dS}{dt} = -\beta S I \] - Rate of change of \( I \): As calculated, \( \frac{dI}{dt} = \beta S I - \gamma I \). - Rate of change of \( R \): \[ \frac{dR}{dt} = \gamma I \] Each equation summarizes how the disease dynamics change with respect to time in this small village's SIR model. This gives a comprehensive insight into the spread of Ebola in this context.

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