Testing for a disease can be made more efficient by combining samples. If the samples from six people are combined and the mixture tests negati) positive sample will always test positive, no matter how many negative samples it is mixed with. Assuming the probability of a single sample testing samples combined into one mixture. Is the probability low enough so that further testing of the individual samples is rarely necessary? The probability of a positive test result is (Round to three decimal places as need.
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When you combine samples from six individuals, each sample has a probability \( p \) of being positive. If we assume the samples are independent, the probability that none of the samples are positive (i.e., all are negative) is \( (1 - p)^6 \). Therefore, the probability of at least one positive sample is given by \( 1 - (1 - p)^6 \), which can give a sense of whether further testing is necessary. For low values of \( p \), this probability can be quite low, so you might only need to retest a handful of individual samples. To determine if further testing is necessary, consider the threshold. If combining the samples leads to a detection probability above a certain threshold (typically around 0.1 or 10%), testing individual samples might become necessary. So, for example, if \( p \) is sufficiently low (e.g., \( p < 0.023 \)), the probability of needing further testing will remain low. You can compute this and round your results to three decimal places for clarity!